Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2
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چکیده
منابع مشابه
Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2
The meiosis-specific synaptonemal complex protein SYCP3 has been reported to be aberrantly expressed in tumours. However, in contrast to its well-defined function in meiosis, its possible role in mitotic cells is entirely unknown. Here, we show that SYCP3 is expressed in a range of primary tumours and that it impairs chromosomal integrity in mitotic cells. Expression of SYCP3 inhibits the homol...
متن کاملStructural components of the synaptonemal complex, SYCP1 and SYCP3, in the medaka fish Oryzias latipes.
The synaptonemal complex (SC) is a meiosis-specific structure essential for synapsis of homologous chromosomes. For the first time in any non-mammalian vertebrates, we have isolated cDNA clones encoding two structural components of the SC, SYCP1 and SYCP3, in the medaka, and investigated their protein expression during gametogenesis. As in the case of mammals, medaka SYCP1 and SYCP3 are express...
متن کاملSingle-molecule observation of DNA compaction by meiotic protein SYCP3
In a previous paper (Syrjänen et al., 2014), we reported the first structural characterisation of a synaptonemal complex (SC) protein, SYCP3, which led us to propose a model for its role in chromosome compaction during meiosis. As a component of the SC lateral element, SYCP3 has a critical role in defining the specific chromosome architecture required for correct meiotic progression. In the mod...
متن کاملGenetic evidence that synaptonemal complex axial elements govern recombination pathway choice in mice.
Chiasmata resulting from interhomolog recombination are critical for proper chromosome segregation at meiotic metaphase I, thus preventing aneuploidy and consequent deleterious effects. Recombination in meiosis is driven by programmed induction of double strand breaks (DSBs), and the repair of these breaks occurs primarily by recombination between homologous chromosomes, not sister chromatids. ...
متن کاملSynaptonemal Complex Protein 3 Transcript Analysis in Breast Cancer
BACKGROUND Breast cancer is the most frequent cancer in women. Cancer/Testis antigens are immunogenic proteins ectopically expressed in human neoplasms. Synaptonemal complex protein 3 (SYCP3) belongs to cancer/testis genes family involved in meiotic events and spermatogenesis. The aim of this study was to express analysis of SYCP3 in breast cancer and validate it as a breast cancer biomarker. ...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2011
ISSN: 1469-221X,1469-3178
DOI: 10.1038/embor.2011.221